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US 2026/0146074 A1Published application
Tag72 targeted chimeric antigen receptor modified t cells for treatment of tag72-positive tumors
AssigneeCity of Hope
InventorsSaul J. Priceman, John P. Murad, Stephen J. Forman, John E. Shively, Paul Yazaki, David Colcher, Anna Kozlowska, Hee Jun Lee
Life of this patent
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Abstract
Chimeric antigen receptors targeted to TAG72 and the use thereof to treat ovarian cancer and other cancers are described.
Claims22
A nucleic acid molecule comprising a nucleotide sequence encoding a chimeric antigen receptor (CAR), wherein the chimeric antigen receptor comprises:
- an scFv targeting Tag-72, a spacer, a transmembrane domain, a CD28 or 41-BB co-stimulatory domain, and a CD3 ζ signaling domain.
Dependencies are inferred from the claim text.