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US 2026/0146062 A1Published application
Compounds and methods for treating diseases caused by viruses and bacteria
AssigneeThe Trustees of Indiana University
InventorsWilliam Leonard Scott, Jack Geno Samaritoni, Martin James O'Donnell
Life of this patent
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Abstract
Compositions and methods are provided for inhibiting the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Claims17
A compound having the general structure of:
- wherein
- R61 is C1-C6 alkyl, (C1-C4 alkyl)R25
- R62 is selected from the group consisting of C1-C5 alkyl,
- R63 is selected from the group consisting of
- R4 is selected from the group consisting of H, C1-C4 alkyl, (C0-C2 alkyl)cyclopropyl, and c-propylmethyl;
- R65 is H, or R62 and R65 together with the atoms to which they are attached form an optionally substituted 5 or 6 membered heterocyclic ring or a 7 membered bicyclic ring, wherein the substituents of the optionally substituted 5 or 6 membered heterocyclic ring are halo, optionally fluorine, optionally wherein the 7 membered bicyclic ring is norbornane;
- R10 is H, halo or —O(C1-C4 alkyl);
- R20 is halo, optionally F or H;
- and
- R25 is halo, CN, CONHR, NHR, COOR, phenyl sulfone, or fluorophenyl, wherein R is H or C1-C4 alkyl.
7 more elements
A compound having the general structure of
- wherein
- R41 is selected from the group consisting of
- R2 is selected from the group consisting of C1-C5 alkyl,
- R3 is C1-C6 alkyl, (C1-C4 alkyl)R25,
- R4 is selected from the group consisting of H, C1-C4 alkyl, (C0-C2 alkyl)cyclopropyl, and c-propylmethyl;
- R5 is H, or R2 and R5 together with the atoms to which they are attached form an optionally substituted 5 or 6 membered heterocyclic ring or a 7 membered bicyclic ring, wherein the substituents of the optionally substituted 5 or 6 membered heterocyclic ring are halo, optionally fluorine, optionally wherein the 7 membered bicyclic ring is norbornane;
- R10 is H, halo or —O(C1-C4 alkyl);
- R20 is halo, optionally F, or H;
- and
- R25 is halo, CN, CONHR, NHR, COOR, phenyl sulfone, or fluorophenyl, wherein R is H or C1-C4 alkyl.
7 more elements
A compound having the general structure of:
- wherein
- R2 is selected from the group consisting of C1-C5 alkyl;
- R3 is
- R5 is H, or R2 and R5 together with the atoms to which they are attached form an optionally substituted 5 or 6 membered heterocyclic ring or a 7 membered bicyclic ring, wherein the substituents of the optionally substituted 5 or 6 membered heterocyclic ring are halo, optionally fluorine, optionally wherein the 7 membered bicyclic ring is norbornane.
1 more element
Dependencies are inferred from the claim text.