Peptidyl nitrile compound and use thereof
AssigneeShanghai Yidian Pharmaceutical Technology Development Co., Ltd
InventorsBin YE, Mingfang ZHENG, Tao YAN
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Abstract
Provided are a peptidyl nitrile compound and a use thereof; specifically provided are a compound represented by formula (I) and/or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound and/or the pharmaceutically acceptable salt thereof, a method for preparing the compound, and a use of the compound in treating diseases caused by cathepsin C and a downstream serine protease thereof.
Claims6
A compound of formula (I) or a pharmaceutically acceptable salt thereof, characterized in that:
- wherein
- Cy is
- A and B are both selected from H;
- X and Y are each independently selected from CH, and Z is selected from CH;
- R2 is selected from hydrogen, fluorine, and q is selected from 1;
- R1 is selected from
- U is selected from —C(═O)—, —O—, —CR8R9—;
- V is selected from —C(═O)—, —O—, —CR8R9—;
- R8 and R9 are hydrogen, or —C1-6 alkyl.
A compound of the following formula (I) or a pharmaceutically acceptable salt thereof:
Dependencies are inferred from the claim text.