US 2026/0146033 A1 · Process of Making 2,2,6,6,7,8,8-heptamethyl-3,6,7,8-tetrahydro-2H-indeno[4,5-b]furan and Its Uses

Abstract

This disclosure relates to a process which involves using 1,1,2,3,3-pentamethyl-5-(2-methylallyl)-1,2,3,5,6,7-hexahydro-4H-inden-4-one (Methallyl Indomuscone) and/or 5-(2-hydroxy-2-methylpropyl)-1, 1,2,3,3-pentamethyl-1,2,3,5,6,7-hexahydro-4H-inden-4-one (Hydroxyisobutyl Indomuscone) as starting material to make 2,2,6,6,7,8,8-heptamethyl-3,6,7,8-tetrahydro-2H-indeno[4,5-b]furan (Aromatic Cyclized Compound). This disclosure also relates to an anaerobic process which involves using Methallyl Indomuscone and/or Hydroxyisobutyl Indomuscone as starting material to make intermediate compound(s) which can be used to make Aromatic Cyclized Compound or 2,2,6,6,7,8,8-heptamethyldecahydro-2H-indeno[4,5-b]furan (Musk Indenofuran). This disclosure also relates to a process for making Musk Indenofuran through Aromatic Cyclized Compound as an intermediate. This disclosure also relates to a one-pot process for making Musk Indenofuran by using Hydroxyisobutyl Indomuscone as the starting material. This disclosure also relates to a phosphine derivative compound of structural formula (X) and a process of making it. wherein R is selected from the group consisting of alkyl group, cycloalkyl group, phenyl group, substituted phenyl group, and perfluorinated alkyl group.

Claims20

Dependent claims

A process comprising:

cyclizing a starting material in the presence of oxygen, an acid catalyst and a solvent in a reaction zone to form 2,2,6,6,7,8,8-heptamethyl-3,6,7,8-tetrahydro-2H-indeno[4,5-b]furan (Aromatic Cyclized Compound), wherein the acid catalyst is a homogeneous acid catalyst with pKa of no more than zero and/or a heterogeneous acid catalyst, and the starting material is 1,1,2,3,3-pentamethyl-5-(2-methylallyl)-1,2,3,5,6,7-hexahydro-4H-inden-4-one (Methallyl Indomuscone) and/or 5-(2-hydroxy-2-methylpropyl)-1,1,2,3,3-pentamethyl-1,2,3,5,6,7-hexahydro-4H-inden-4-one (Hydroxyisobutyl Indomuscone).

Dependencies are inferred from the claim text.

Process of Making 2,2,6,6,7,8,8-heptamethyl-3,6,7,8-tetrahydro-2H-indeno[4,5-b]furan and Its Uses

Life of this patent

Process of Making 2,2,6,6,7,8,8-heptamethyl-3,6,7,8-tetrahydro-2H-indeno[4,5-b]furan and Its Uses

Life of this patent

Abstract

Claims20