Reblastatin derivative and its use in nervous system diseases
AssigneeChinese Academy of Medical Sciences, Institute of Basic Medical Sciences
InventorsQi Xu, Longze Sha, Xiaoming YU, Yunfeng Li
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Abstract
A reblastatin derivative and its use in nervous system diseases. By modifying the 18-position hydroxyl of reblastatin, the therapeutic activity of the nervous system can be improved. In addition, especially when it is replaced with a methyl group, the lipid solubility of the compound can be increased, so that the brain-passing efficiency is improved.
Claims11
-14. (canceled)
A reblastatin derivative or a pharmaceutically acceptable salt of the reblastatin derivative, and a structural formula of the reblastatin derivative is shown in Formula I:
- wherein, the R is selected from methyl, —OCO—Ra,
- the Ra is selected from dimethylamino group,
-20. (canceled)
Dependencies are inferred from the claim text.