Tetrafluoroethylene copolymer compositions and associated methods
AssigneeW. L. Gore & Associates, Inc.
InventorsValerie R. Binetti, James L. Goepfrich, Amanda Kamps, David J. Minor, Brandon C. Short, Peter D. Traylor
Life of this patent
Estimating the term…
Abstract
The present disclosure is directed to a class of fluorinated copolymers, such as TFE copolymers, that can be dispersed in a liquid carrier including low toxicity liquid solvents, such as Class III Solvents, and that enable the creation of stable dispersions including the fluorinated copolymers dispersed in a liquid carrier including a water miscible organic component and an aqueous component.
Claims75
A composition comprising:
- a tetrafluoroethylene copolymer dispersed in a liquid carrier;
- wherein a first ratio of a weight of the tetrafluoroethylene copolymer to a volume of the liquid carrier is from about 0.01 g/ml to about 0.1 g/ml.
The composition of any of the preceding claims, wherein the liquid carrier comprises a water miscible organic component and an aqueous component;
- wherein the ratio of the water miscible organic component to the aqueous component is from about 1:1 to about 4:1.
The composition of any of the preceding claims, wherein the tetrafluoroethylene copolymer comprises a hydroxyl functional group.
The composition of any of the preceding claims, wherein the tetrafluoroethylene copolymer is poly(tetrafluoroethylene-co-vinyl alcohol) (TFE-VOH).
The composition of any of the preceding claims, wherein the tetrafluoroethylene copolymer has a molecular weight of from about 50,000 g/mol to about 500,000 g/mol.
The composition of any of the preceding claims, wherein the tetrafluoroethylene copolymer has a molecular size of from about 33 nm to about 165 nm.
The composition of any of the preceding claims, wherein the composition is configured to be injected into a target space to form a gel that occludes at least a portion of the space.
A method of preparing a composition comprising:
- mixing a tetrafluoroethylene copolymer with a water miscible organic component to form a mixture;
- mixing an aqueous component with the mixture to form a kinetically stable dispersion;
- and
- wherein the composition comprises the tetrafluoroethylene copolymer uniformly distributed throughout a liquid carrier comprising the water miscible organic component and the aqueous component.
A method of preparing a composition comprising:
- mixing a tetrafluoroethylene copolymer with a liquid carrier comprising a water miscible organic component and an aqueous component to form a kinetically stable dispersion;
- and
- wherein the composition comprises the tetrafluoroethylene copolymer uniformly distributed throughout a liquid carrier comprising the water miscible organic component and the aqueous component.
A method of preparing a composition comprising:
- mixing a tetrafluoroethylene copolymer with a water miscible organic component to form a mixture;
- mixing an aqueous component with the mixture to form a kinetically stable dispersion;
- and
- wherein the composition comprises the tetrafluoroethylene copolymer uniformly distributed throughout a liquid carrier comprising the water miscible organic component and the aqueous component.
A method of preparing a composition comprising:
- mixing a tetrafluoroethylene copolymer with a liquid carrier comprising a water miscible organic component and an aqueous component to form a kinetically stable dispersion;
- and
- wherein the composition comprises the tetrafluoroethylene copolymer uniformly distributed throughout a liquid carrier comprising the water miscible organic component and the aqueous component.
A method comprising:
- providing a composition comprising a tetrafluoroethylene copolymer uniformly distributed throughout a liquid carrier, the liquid carrier comprising a water miscible organic component and an aqueous component;
- introducing the composition into a patient at a target space;
- and
- diffusing the water miscible organic component into the patient to form a gel comprising the tetrafluoroethylene copolymer at the target space.
A method of treating disease by providing distal embolization comprising providing a composition including a tetrafluoroethylene copolymer uniformly distributed throughout a liquid carrier, the liquid carrier including a water miscible organic component and an aqueous component;
- and deploying the composition through a delivery system operable to deliver the composition to a target site.
Dependencies are inferred from the claim text.