In vivo crosslinkable hydrogels with gold nanoparticles for medical applications
AssigneeBoston Scientific Scimed, Inc.
InventorsRick William Dorn, Joseph Thomas Delaney, JR.
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Abstract
In some aspects, the present disclosure pertains to systems that comprise (a) a reactive polymer comprising a plurality of first hydrophilic polymer segments and a plurality of first reactive moieties, (b) a reactive multifunctional compound comprising a plurality of second reactive moieties, and (c) gold nanoparticles that are functionalized with a plurality of second hydrophilic polymer segments. In other aspects, the present disclosure pertains to crosslinked reaction products formed from such systems. In further aspects, the present disclosure pertains to methods of treatment using systems and such crosslinked reaction products.
Claims20
A system comprising (a) a reactive polymer comprising a plurality of first hydrophilic polymer segments and a plurality of first reactive moieties, (b) a reactive multifunctional compound comprising a plurality of second reactive moieties, and (c) gold nanoparticles that are functionalized with a plurality of second hydrophilic polymer segments.
A method of treatment comprising administering to a subject a mixture that comprises a reactive polymer comprising a plurality of first hydrophilic polymer segments and a plurality of first reactive moieties, a reactive multifunctional compound comprising a plurality of second reactive moieties, and gold nanoparticles that are functionalized with a plurality of second hydrophilic polymer segments, under conditions such that the reactive polymer and the multifunctional compound crosslink after administration to form a crosslinked hydrogel in which the gold nanoparticles are retained in the crosslinked hydrogel via non-covalent interactions.
A crosslinked hydrogel comprising gold nanoparticles retained via non-covalent interactions in a crosslinked reaction product of (a) a reactive polymer comprising a plurality of first hydrophilic polymer segments and a plurality of first reactive moieties and (b) a reactive multifunctional compound comprising a plurality of second reactive moieties, wherein the gold nanoparticles are functionalized with a plurality of second hydrophilic polymer segments.
Dependencies are inferred from the claim text.