Back to results
US 2026/0144877 A1Published application
High capacity diketopiperazine microparticles and methods
AssigneeMannKind Corporation
InventorsMarshall Grant, Paul Menkin, Grayson W. Stowell
Life of this patent
Estimating the term…
Abstract
Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
Claims21
A pulmonary drug delivery system comprising:
- an inhaler;
- a unit dose dry powder medicament container adaptable to said inhaler;
- and
- a dry powder within the unit dose dry powder medicament container comprising synthesized diketopiperazine microparticles and a drug or an active agent, the diketopiperazine microparticles comprising a plurality of structural domains, each structural domain comprising a nucleus surrounded by layers of a porous crystalline material, and having a mass-weighted average particle size of about 33,000 to about 216,000 voxels measured by X-ray tomography for a particle size measuring about 0.5 μm to about 4 μm in geometric size.
1 more element
-26. (canceled)
Dependencies are inferred from the claim text.