Methods of treating eye diseases using optic nerve lamina region neural progenitor cell-derived secreted extracellular vesicles and free proteins
AssigneeUniversity of Maryland, Baltimore
InventorSteven Lance BERNSTEIN
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Abstract
Soluble proteins and extracellular vesicles (EVs) produced by optic nerve lamina region neural progenitor cells (ONLR-NPCs) are provided. Such proteins and EVs include growth factors and survival factors that can be used in the treatment of optic nerve diseases, such as glaucoma. Also provided are methods of treating or preventing optic nerve diseases, such as glaucoma, using ONLR-NPC-based compositions.
Claims19
A method of (a) treating or preventing an optic nerve disease, (b) enhancing retinal ganglion cell (RGC) survival, and/or (c) enhancing RGC neurite outgrowth in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising one or more of:
- (i) optic nerve lamina region neural progenitor cell (ONLR-NPC)-secreted soluble proteins,
- (ii) a population of ONLR-NPC-produced extracellular vesicles (EVs),
- (iii) ONLR-NPC conditioned media containing ONLR-NPC-secreted soluble proteins and/or ONLR-NPC-produced EVs,
- (iv) ONLR-NPC EV lysates, and
- (v) ONLR-NPC EV extracts,
- thereby (a) treating or preventing an optic nerve disease, (b) enhancing retinal ganglion cell (RGC) survival, and/or (c) enhancing RGC neurite outgrowth in the subject.
Dependencies are inferred from the claim text.