Immunocompatible chorionic membrane products
AssigneeOsiris Therapeutics, Inc.
InventorsSamson TOM, Alla DANILKOVITCH, Dana YOO, Timothy JANSEN, Jin-Qiang KUANG, Jennifer Michelle MARCONI
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Abstract
Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
Claims20
A preserved chorionic membrane comprising viable cells native to the chorionic membrane,
- wherein the viable cells comprise two or more of mesenchymal stem cells (MSCs), stromal cells, and fibroblast cells, and
- wherein the preserved chorionic membrane is immunocompatible and substantially free of CD14+ macrophages, trophoblasts, vascularized tissue, vascularized tissue-derived immunogenic cells, and immunogenic maternal cells.
Dependencies are inferred from the claim text.