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US 2026/0144810 A1Published application
mRNA COMPOSITION FOR TREATING CANCER, PREPARATION CONTAINING THE SAME AND USE THEREOF
AssigneeIndustrial Technology Research Institute
InventorsMin-Yuan CHOU, Yen-Ju LIN, Ming-Hua YANG, Ya-Ping LAI, Mei-Wei LIN, Li-Tsen LIN, Yu-Jia TZENG, Ssu-Yuan WU, Chin Pen LAI
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Abstract
An mRNA composition for treating cancer is provided. The mRNA composition for treating cancer includes an mRNA encoding a CD47-targeted chimeric antigen receptor (CAR) and an mRNA encoding interleukin-12 (IL-12).
Claims20
An mRNA composition for treating cancer, comprising:
- an mRNA encoding a CD47-targeted chimeric antigen receptor (CAR);
- and
- an mRNA encoding interleukin-12 (IL-12).
A lipid nanoparticle preparation for treating cancer, comprising:
- a lipid nanoparticle;
- an mRNA encoding a CD47-targeted chimeric antigen receptor;
- and
- an mRNA encoding interleukin-12,
- wherein the lipid nanoparticle is loaded with the mRNA encoding a CD47-targeted chimeric antigen receptor and the mRNA encoding interleukin-12.
2 more elements
A method for treating cancer, comprising:
- administering an mRNA composition for treating cancer to a subject in need thereof,
- wherein the mRNA composition for treating cancer comprises:
- an mRNA encoding a CD47-targeted chimeric antigen receptor;
- and
- an mRNA encoding interleukin-12;
- wherein the mRNA composition for treating cancer is capable of polarizing an M2 macrophage into an M1 macrophage to secrete interleukin-12 and form a CD47-targeted chimeric antigen receptor-macrophage in a subject in need thereof.
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Dependencies are inferred from the claim text.