Compositions and methods for preventing or treating muscle conditions
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsHelen M. Blau, Adelaida R. Palla, Andrew Tri Van Ho
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Abstract
Provided herein are compositions for preventing or treating muscle conditions such as muscle damage, injury, or atrophy. In some embodiments, the compositions comprise a prostaglandin E2 (PGE2) compound and a myotoxin. In some embodiments, the muscle damage, injury, or atrophy is the result of a nerve injury, a surgical procedure, or a traumatic injury. Methods of promoting muscle regeneration and methods of increasing muscle mass are also provided herein.
Claims18
A method of treating a muscle condition or a muscle disease in a subject, the method comprising:
- (a) administering a compound that attenuates PGE2 catabolism to the subject;
- and
- (b) administering a myotoxin to the subject,
- wherein the compound that attenuates PGE2 catabolism and the myotoxin are administered to the subject in amounts effective to treat the muscle condition or the muscle disease.
Dependencies are inferred from the claim text.