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US 2026/0144758 A1Published application
Hollow Hydroxyapatite Microparticles for Controlled Release of Osteoprotegerin and Their Use in Orthodontic and Bone Regenerative Therapies
AssigneeThe Regents of the University of California
InventorsSunil Kapila, Tejal A. Desai, Darnell Cuylear
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Abstract
Hollow hydroxyapatite microparticles are provided for sustained delivery of an agent that provides osteoprotegerin anti-osteolytic activity for treatment of post-orthodontic relapse and bone disorders. In particular, methods of using such microparticles for post-orthodontic tooth stabilization and bone regeneration and repair are provided.
Claims30
A microparticle comprising:
- a) a hollow core;
- b) a layer of hydroxyapatite encapsulating the hollow core;
- and
- c) an agent that provides osteoprotegerin anti-osteolytic activity for bone regeneration or post-orthodontic tooth stabilization, wherein the agent that provides osteoprotegerin is contained within the hollow core.
1 more element
Dependencies are inferred from the claim text.