Systems and methods for angiography using multi-energy detectors

A system for generating a plurality of basis images for use in angiography, the system comprising:

• at least one computer;
• at least one electronic storage device;
• the at least one electronic storage device storing instructions that, when executed by the at least one computer, cause the at least one computer to generate a plurality of basis images by performing actions comprising:
• acquiring at least four radiological measurements of a target image region, wherein the at least four radiological measurements include:
• a pre-injection measurement set including at least a first pre-injection measurement and a second pre-injection measurement;
• and
• a post-injection measurement set including at least a first post-injection measurement and a second post-injection measurement;
• decomposing, using a joint estimate, the at least four radiological measurements into at least four basis images, the at least four basis images comprising:
• a pre-injection first material basis image, a post-injection first material basis image, a second material basis image, and a contrast agent basis image, wherein the decomposing the at least four radiological measurements into at least four basis images comprises performing at least three-material decomposition using all of the at least four radiological measurements;
• and
• providing at least the contrast agent basis image.