In-vitro tissue model and test method
AssigneeOtsuka Medical Devices Co., Ltd.
InventorsLiang ZHAI, Gexsy NAVA
Life of this patent
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Abstract
An in-vitro tissue model for use with a test article includes a tissue sample that includes homogeneous tuna meat having an isotropic thermal response, wherein the tuna meat is characterized by a plurality of visually distinct color states, each color state corresponding to a respective temperature to which the tuna meat has been heated within a range of 43° C. to 60° C., thereby providing a visual indication of the thermal effect of the test article within said range.
Claims38
An in-vitro tissue model for use with a test article, comprising:
- a tissue sample that includes homogeneous tuna meat having an isotropic thermal response;
- wherein the tuna meat is characterized by a plurality of visually distinct color states, each color state corresponding to a respective temperature to which the tuna meat has been heated within a range of 43°C to 60°C, thereby providing a visual indication of the thermal effect of the test article within said range.
An in-vitro test kit for use with a test article having at least one energy emitter, comprising:
- a tissue holder;
- and
- an in-vitro tissue model for use with the test article, the in-vitro tissue model comprising:
- a tissue sample that includes homogeneous tuna meat having an isotropic thermal response, wherein the tuna meat is characterized by a plurality of visually distinct color states, each color state corresponding to a respective temperature to which the tuna meat has been heated within a range of 43°C to 60°C, thereby providing a visual indication of the thermal effect of the test article within said range, wherein the in-vitro tissue model is configured to be held by the tissue holder, and wherein the tissue holder is configured to maintain the in-vitro tissue model in a predetermined spatial relationship relative to the at least one energy emitter.
A test method, comprising:
- providing an in-vitro tissue model comprising a tissue sample that includes homogeneous tuna meat having an isotropic thermal response;
- placing a tissue treatment device in proximity to the tissue sample;
- delivering, by the tissue treatment device, ablation energy into the tissue sample to cause a change in color of the tuna meat;
- and
- characterizing a performance parameter of the tissue treatment device based on the change in color.
A medical ablation catheter system, comprising:
- an energy emitter configured to deliver ablation energy;
- and
- a controller operably coupled to the energy emitter, the controller having a set of operational parameters stored therein for controlling the delivery of ablation energy;
- wherein said set of operational parameters is determined by a method comprising:
- (a) delivering ablation energy from a test catheter to an in-vitro tissue model comprising homogeneous tuna meat having an isotropic thermal response;
- (b) observing a plurality of visually distinct color states in the tuna meat corresponding to a range of temperatures between 43°C and 60°C;
- and
- (c) selecting the set of operational parameters based on the observed color states to achieve a desired therapeutic effect.
Dependencies are inferred from the claim text.