Combination of antibody-drug conjugate and tubulin inhibitor
AssigneeDaiichi Sankyo Company, Limited
InventorsYusuke OGITANI, Chiaki ISHII, Yasuki KAMAI, Kiyoshi SUGIHARA, Shotaro NAGASE
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Abstract
A pharmaceutical composition, wherein an antibody-drug conjugate in which a drug-linker represented by the following formula (wherein A represents a connecting position to an antibody) is conjugated to the antibody via a thioether bond, and a tubulin inhibitor are administered in combination, and a method of treatment, wherein the antibody-drug conjugate and the tubulin inhibitor are administered in combination to a subject.
Claims22
A method of treating cancer, said method comprising administering a first antibody-drug conjugate and administering a tubulin inhibitor to a subject in need of such treatment, wherein
- the first antibody-drug conjugate is an antibody-drug conjugate in which a drug-linker represented by the following formula is conjugated to an antibody via a thioether bond:
- wherein A represents a connecting position to the antibody,
- the antibody in the first antibody-drug conjugate is an anti-HER3 antibody, an anti-B7-H3 antibody, or an anti-CDH6 antibody, and
- the tubulin inhibitor is a second antibody-drug conjugate in which DM4 is conjugated to an antibody via a linker.
Dependencies are inferred from the claim text.