Lurbinectedin crystal form and method for preparing same
AssigneeShanghai Haoyuan Chemexpress Co., Ltd.
InventorsHoujia ZHOU, Kaimin QIAN, Lingli CAI, Qiang GAO, Baofu ZHENG
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AssigneeShanghai Haoyuan Chemexpress Co., Ltd.
InventorsHoujia ZHOU, Kaimin QIAN, Lingli CAI, Qiang GAO, Baofu ZHENG
Estimating the term…
Provided is a lurbinectedin crystal form having characteristic absorption peaks at diffraction angles 2θ of 4.55±0.2°, 6.16±0.2°, 7.61±0.2°, 9.17±0.2°, 9.54±0.2°, and 9.89±0.2° in an X-ray powder diffraction pattern using a Cu-Kα radiation source. Also provided are novel lurbinectedin crystal forms II, III, IV, and V. The crystal forms I-V features high purity, good stability, good solubility and the like, the absence of the problems of difficulties in filtration and static electricity in the prior art, a simple preparation method, available and cost-efficient solvents, mild crystallization conditions, and suitability for industrial mass production.
A polymorph of the compound represented by Formula (I), wherein the polymorph is selected from the group consisting of crystal form I, crystal form II, crystal form III, crystal form IV, and crystal form V,
Dependencies are inferred from the claim text.