Heteroarylation of diverse quaternary carbon centers of free carboxylic acids
AssigneeThe Scripps Research Institute
InventorsJin-Quan YU, Liang HU, Guangrong MENG
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Abstract
The application provides methods of β- and γ-C(sp3)-H heteroarylation of diverse quaternary carbon centers of free aliphatic carboxylic acids using bidentate pyridine-pyridone ligands. Herein disclosed are methods of Pd(II)-catalyzed mono-selective β- and γ-C(sp3)-H aza-heteroarylation of free carboxylic acids, including a-hydrogen containing substrates, with high yields and high mono-selectivity.
Claims70
A method of β- or γ-C(sp3)-H heteroarylation of aliphatic carboxylic acids, comprising treating an aliphatic carboxylic acid with a bidentate pyridine-pyridone ligand in the presence of a Pd(II) catalyst.
Any method of β- or γ-C(sp3)-H heteroarylation of aliphatic carboxylic acids as disclosed herein.
Dependencies are inferred from the claim text.