Cell delivery injector

A system for delivering a cell therapy to a patient, comprising:

• a container configured to hold a therapeutic composition, the therapeutic composition comprising one or more cells in a suspension;
• at least one powered drive in operative connection with the container, the at least one powered drive being configured to pressurize the therapeutic composition within the container and at least one fluid line in communication therewith;
• a control system having a plurality of sensors and at least one processor programmed or configured to receive data from the plurality of sensors and, based at least in part on the data, to control the at least one powered drive so as to pressurize the therapeutic composition within the container and the at least one fluid line and thereby to inject the therapeutic composition into the patient at a first flow rate;
• the plurality of sensors including at least two of:
• a pressure sensor for measuring and providing data indicative of pressure within the container and the at least one fluid line,
• a flow sensor for measuring and providing data indicative of an actual flow rate of the suspension within the at least one fluid line,
• a counting sensor for providing data indicative of a count within the suspension flowing through the at least one fluid line of at least one of (i) a number of the one or more cells that remain whole and (ii) a number of the one or more cells that have ruptured,
• a site sensor for placement about a site of injection of the suspension into the patient and for providing data indicative of one of an occurrence and a non-occurrence of an extravasation thereat,
• a temperature sensor for measuring and providing data indicative of a temperature of the suspension within the at least one fluid line,
• a chemical sensor for detecting and providing data indicative of an occurrence of an immune response in the patient, and
• at least one physiological sensor for measuring and providing data indicative of at least one parameter of the patient;
• wherein the at least one processor is further programmed or configured to control the at least one powered drive to pressurize the therapeutic composition within the container and thereby to inject the therapeutic composition into the patient at a second flow rate upon determining that the data received from the plurality of sensors indicate at least one of:
• the pressure within at least one of the container and the at least one fluid line is greater than a predetermined pressure threshold;
• the flow rate of the suspension within the at least one fluid line is greater than a predetermined flow rate threshold;
• the number of the one or more cells within the suspension that have ruptured is greater than a predetermined rupture threshold;
• the occurrence of an extravasation threat about the site of the injection;
• the temperature of the suspension within the at least one fluid line is outside a predetermined temperature range;
• the occurrence of an immune response in the patient as evidenced by the data received from at least one of the chemical sensor and the at least one physiological sensor;
• and
• an adverse reaction experienced by the patient as evidenced by the data received from the at least one physiological sensor.