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US 2026/0137839 A1Published application
Controlled hydrogel delivery of focal adhesion kinase inhibitor for decreased scar formation
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsGeoffrey C. GURTNER, Sun Hyung KWON, Mohammed Inayathullah NAZIR AHMED, Jayakumar RAJADAS
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Abstract
The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) formulated in a pullulan hydrogel. The release profile of the FAK inhibitor can be adjusted according to the nature of the wound, e.g., excisional wounds, burn wounds, etc.
Claims20
A composition for use in promoting tissue healing, and forming new hair and skin appendages, comprising:
- a porous scaffold comprising a pullulan-collagen hydrogel;
- and
- focal adhesion kinase (FAK) inhibitor disposed in pores of the scaffold,
- wherein the composition is configured for sustained release of the FAK inhibitor disposed in pores of the scaffold to deliver a dose of the FAK inhibitor to the tissue effective to promote tissue healing at a controlled rate during a treatment time and forming new hair growth or skin appendages in the tissue.
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Dependencies are inferred from the claim text.