US 2026/0137814 A1 · FLUORESCENT COMPOUNDS FOR ACCELERATED CANCER THERANOSTIC

Abstract

The present invention discloses aggregation-induced emission fluorescent compounds with near-infrared (NIR) emission. This fluorescent compound is then encapsulated by polymer matrix to yield nanoaggregates which is confirmed to show an excellent photothermal conversion efficiency while maintaining a high fluorescence quantum yield. Consequently, the photothermal therapeutic efficacy can be improved by PTA-oriented accumulation of nanoaggregates, compared with the barely enhanced permeability and retention (EPR) effect. The in vitro and in vivo verification further confirmed that the nanoaggregates exhibit superior fluorescence-guided phototheranostics ability to eliminate tumors.

Claims32

Dependent claims

A fluorescent compound exhibiting aggregation-induced emission properties, the fluorescent compound having a backbone structural formula selected from the group consisting of:

wherein R is selected from the group consisting of straight-chain, branched, cyclic alkyl, alkyl phenyl, alkyl thienyl and other alkyl aryl with 2-40 C atoms, wherein one or more non-adjacent C atoms are optionally replaced by —O—, —S—, —C(O)—, —C(O—)—O—, —O—C(O)—, —O—C(O)—O—, or —C≡C—and wherein one or more H atoms are optionally replaced by F, Cl, Br, I, or CN or denote aryl, heteroaryl, aryloxy, heteroaryloxy, arylcarbonyl, heteroarylcarbonyl, arylcarbonyloxy, heteroarylcarbonyloxy, aryloxycarbonyl, or heteroaryloxycarbonyl having 4 to 30 ring atoms unsubstituted or substituted by one or more non-aromatic groups;
wherein each π is independently selected from the group consisting of:
wherein each X is independently selected from the group consisting of:

Dependencies are inferred from the claim text.

Fluorescent compounds for accelerated cancer theranostic

Life of this patent

Fluorescent compounds for accelerated cancer theranostic

Life of this patent

Abstract

Claims32