Polymeric nanovaccines and uses thereof
AssigneeRamot at Tel-Aviv University Ltd.
InventorsRonit SATCHI-FAINARO, Helena FLORINDO, Joao CONNIOT, Anna SCOMPARIN
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Abstract
A polymeric nanoparticle is disclosed which comprises: (i) at least one disease-associated antigen which is capable of producing a T-cell response, wherein the disease-associated antigen is encapsulated in the nanoparticle; (ii) at least one adjuvant; and (iii) a dendritic cell targeting moiety which is attached to the outer surface of the nanoparticle. Use of the nanoparticle for treating diseases associated with abnormal cell growth or an infection is also disclosed.
Claims13
A vaccine comprising a pharmaceutically acceptable carrier and a polymeric nanoparticle which comprises:
- (i) at least one disease-associated antigen which is capable of producing a T-cell response, wherein the disease-associated antigen is encapsulated in the nanoparticle;
- (ii) at least one Toll-like receptor (TLR) ligand;
- (iii) a dendritic cell targeting moiety comprising mannose which is attached to the outer surface of the nanoparticle;
- and
- (iv) d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS).
Dependencies are inferred from the claim text.