Fluorescent compounds for synergistic photodynamic and photothermal cancer theranostic
AssigneeThe Hong Kong University of Science and Technology
InventorsBEN-ZHONG TANG, HUILIN XIE, TSZ KIN KWOK
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Abstract
The present invention discloses aggregation-induced emission fluorescent compounds with near-infrared (NIR) emission. The present invention also shows application for imaging-guided phototheranostic with the integration of both photodynamic therapies and photothermal therapies. The in vitro and in vivo verification further confirmed that this system exhibits outstanding fluorescence-guided phototheranostics ability to eliminate tumors effectively.
Claims21
A fluorescent compound exhibiting aggregation-induced emission properties, the fluorescent compound having a backbone structural formula selected from the group consisting of:
- wherein each R1, R2, and R3 is independently selected from the group consisting of straight-chain, branched, cyclic alkyl, alkyl phenyl, alkyl thienyl and other alkyl aryl with 2-40 C atoms, wherein one or more non-adjacent C atoms are optionally replaced by —O—, —S—, —C(O)—, —C(O—)—O—, —O—C(O)—, —O—C(O)—O—, —CR5=CR6-, or —C≡C—, and wherein one or more H atoms are optionally replaced by F, Cl, Br, I, or CN or denote aryl, heteroaryl, aryloxy, heteroaryloxy, arylcarbonyl, heteroarylcarbonyl, arylcarbonyloxy, heteroarylcarbonyloxy, aryloxycarbonyl, or heteroaryloxycarbonyl having 4 to 30 ring atoms unsubstituted or substituted by one or more non-aromatic groups;
- wherein each R4 and R5 is independently selected from the group consisting of:
Dependencies are inferred from the claim text.