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US 2026/0137779 A1Published application
Cancer-targeted, virus-encoded, regulatable t (catvert) or nk cell (catvern) linkers
AssigneeThe Research Institute at Nationwide Children' s Hospital
InventorsTimothy P. Cripe, Chun-yu Chen, Brian Hutzen, Mark Currier, Pin-yi Wang, Dawn Chandler
Life of this patent
Estimating the term…
Abstract
Recombinant polynucleotides and vectors containing an engineered (artificial) exon-intron-exon gene structure in a transgene are provided, which undergoes splicing when it is expressed in a target cell.
Claims36
1-31. (canceled)
A recombinant adeno-associated viral (rAAV) vector, comprising from 5′ to 3′:
- (a) a 5′ AAV inverted terminal repeat (ITR);
- (b) a promoter;
- (c) a polynucleotide encoding a secretion sequence;
- (d) a transgene encoding a dimert;
- and
- (e) a 3′ AAV ITR.
3 more elements
A recombinant adeno-associated viral (rAAV) vector, comprising from 5′ to 3′:
- (a) a 5′ AAV inverted terminal repeat (ITR);
- (b) a promoter;
- (c) a polynucleotide encoding a secretion sequence;
- (d) a transgene encoding a fusion protein comprising:
- (i) a first antigen binding fragment that binds CD3 and a second antigen binding fragment that binds CD19;
- or a first antigen binding fragment that binds CD19 and a second antigen binding fragment that binds CD3;
- or
- (ii) a first antigen binding fragment that binds CD3 and a second antigen binding fragment that binds GD2;
- or a first antigen binding fragment that binds GD2 and a second antigen binding fragment that binds CD3;
- and
- (e) a 3′ AAV ITR.
8 more elements
Dependencies are inferred from the claim text.