MODULATORS OF RAR RELATED ORPHAN RECEPTORS (RORs)

A compound of Formula (I), (II), (III), or (IV) a pharmaceutically acceptable salts thereof, or stereoisomers thereof:

• wherein
• R1, R2, R3, or R4 groups are H, halogen, NO2, 1-6 alkoxy, OH, NH2, 1-6 alkyl, 1-6 alkenyl, 1-6 haloalkyl, N-dialkyl, haloalkoxy, 1-6 hydroxyalkyl, or —CO2(1-6 alkyl);
• R5 is a substituted or unsubstituted, five or six membered saturated or unsaturated heterocycle, alkylarene, ring substituted alkylarene, ring substituted alkylcyclohexane, ring substituted alkylcyclopentane, phenyl, substituted phenyl, benzyl, pyrimidine, imidazole, diazole, triazole, thiadiazole, imidazolidine, thiazolidine, pyrrolidine, piperazine, piperidine, pyridazine, pyrazine, triazine, 1H pyrrole, 2H pyrrole, pyrroline, pyrazolidine, pyrazoline, thiazole, isothiazole, isoxazole, methylpyrimidine, methylpyridine, methylimidazole, methyldiazole, methyltriazole, methylthiadiazole, methylimidazolidine, methylthiazolidine, methylpyrrolidine, methylpiperazine, methylpiperidine, methylpyridazine, methylpyrazine, methyltriazine, methylpyrrole, methylpyrroline, methylpyrazolidine, methylpyrazoline, methylthiazole, methylisothiazole, methylisoxazole, morpholine, arylalkyl or substituted cyclohexane;
• R6 is H, 1-6 alkyl, or may form a five or six ring structure with R5;
• and
• R7 is a substituted or unsubstituted, five or six membered saturated or unsaturated heterocycle, ring substituted alkylarene, ring substituted alkylcyclohexane, ring substituted alkylcyclopentane, substituted phenyl, benzyl, pyrimidine, pyridine, imidazole, diazole, triazole, thiadiazole, imidazolidine, thiazolidine, pyrrolidine, piperazine, alkylarene, piperidine, pyridazine, pyrazine, triazine, 1H pyrrole, 2H pyrrole, pyrroline, pyrazolidine, pyrazoline, thiazole, isothiazole, isoxazole, methylpyrimidine, toluene, methylpyridine, methylimidazole, methyldiazole, methyltriazole, methylthiadiazole, methylimidazolidine, methylthiazolidine, methylpyrrolidine, methylpiperazine, methylpiperidine, methylpyridazine, methylpyrazine, methyltriazine, methylpyrrole, methylpyrroline, methylpyrazolidine, methylpyrazoline, methylthiazole, methylisothiazole, methylisoxazole, trifluoromethyl, or pyrazole;
• with the proviso that the compound is not a compound of Formula (II), pharmaceutically acceptable salts thereof, or stereoisomers thereof, wherein R7 is pyrimidine and R5 is a methylpyridine;
• and
• with the proviso that the compound is not a compound of Formula (IV), pharmaceutically acceptable salts thereof, or stereoisomers thereof, wherein R7 is pyridine, toluene or substituted phenyl, and R5 is a substituted phenyl or an arylalkyl.