Oral Film with Multiple Regions for Therapy of Periodontal and Dental Diseases or Disorders

The film (5) of any of the preceding claims, wherein the first region (1) is adjacent to the second region (2) in the first surface (4).

The film (5) of any of the preceding claims, wherein said first region (1) is formed by a first sheet (10) and said second region (2) is formed by a second sheet (20), wherein surfaces of said first and second sheets (10, 20) together form the first surface (4).

The film (5) of any of the preceding claims, wherein the first sheet (10) and the second sheet (20) forming the first surface (4) are arranged on a backing layer (30) forming a second surface (6) opposite to the first surface (4),

• wherein, optionally, the backing layer (30) is configured to inhibit diffusion of at least one of the active agents towards the oral mucosa of the subject.

The film (5) of any of the preceding claims, wherein the film (5) or at least one sheet thereof comprises a polymeric material and/or a hydrogel as a matrix material,

• wherein the matrix material optionally comprises a vinyl polymer, polyacrylate, PEEK (polyether ether ketone) polymer, carbopol, natural polymer, or copolymers thereof, or pectin coated liposomes.

The film (5) of any of the preceding claims, wherein the film (5) or at least one sheet thereof comprises polyvinyl acetate (PVA), polyvinylpyrrolidone (PVP) and/or hydroxypropylmethylcellulose (HPMC), optionally, PVA.

The film (5) of any of the preceding claims, wherein the film (5) or at least one sheet thereof comprises PVP.

The film (5) of any of the preceding claims, wherein the film (5) or at least one sheet thereof comprises HPMC.

The film (5) of any of the preceding claims, wherein the film (5) or at least one sheet thereof comprises a plasticizer, optionally, glycerol or PEG-400, preferably, glycerol.

The film (5) of any of the preceding claims, wherein the first active agent is selected from the group consisting of a peroxide, an agent capable of generating a peroxide, a self-assembling peptide, CPP-ACP, mineral particles, and fluoride.

The film (5) of any of the preceding claims, wherein the second active agent is selected from the group consisting of an anti-inflammatory agent, a senolytic agent, a botanical agent, an anti-bacterial agent, and a self-assembling peptide.

A pharmaceutical film (5) of any of the preceding claims,

• optionally, for use in therapy of at least one periodontal or dental disease or disorder selected from the group comprising caries, mucositis, gingivitis, periodontitis, peri-implantitis and tooth discoloration in a subject.