Methods to reduce contamination, biofilm and fouling from water systems, surfaces, and products
AssigneeAequor, Inc.
InventorCynthia K. Burzell
Life of this patent
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Abstract
The present disclosure describes compositions comprising one or more organophosphorous or organosulfuous compounds for treating contaminants in a liquid or a liquid composition, for killing, preventing, and/or inhibiting the growth of microorganisms on surfaces, and for increasing the biomass of yeast or algae in culture. The compositions are also useful for treating contaminants in yeast fermentation broth and for cleaning or protecting surfaces from the growth of microorganisms.
Claims18
A composition comprising one or more organophosphorous and/or organosulfurous compounds, salts thereof, solvates thereof, or derivatives thereof, in an effective amount to clean a surface, to prevent formation of biofilm, to prevent fouling, to kill microbes, and/or to inhibit the growth of microbes, wherein the organophosphorous and/or organosulfurous compound has the structure of Formula I, Formula II, or Formula III, and wherein
- (a) Formula I is
- wherein,
- A is H, C1-16 hydrocarbyl or optionally R1 substituted C1-16 hydrocarbyl;
- Z is O or a bond;
- Y is O;
- G is OH, H, C1-6—COO-alkyl, —O—C1-16 alkyl, R1 substituted C1-10 hydrocarbyl, CH2NHCH2COOH, or O-aryl;
- X is H, CN, —NHR, —NHOR, —NHOCOR, R1 substituted C1-10 hydrocarbyl or —OR;
- and R is H, C1-10 hydrocarbyl, or optionally R1 substituted C1-10 hydrocarbyl;
- R1 is selected from halogen, cyano, OH, C1-6 hydrocarbyl, C1-6 alkoxy, SOR2, SO2R2, SO2NR3R4, CONR3R4, NR3R4, NR3COR4, NR3SO2R4, NR3CO2R4, NR3CONR4, and phosphonic acid, wherein each of C1-6 hydrocarbyl, C1-6 alkoxy, SOR2, SO2R2, SO2NR3R4, CONR3R4, NR3R4, NR3COR4, NR3SO2R4, NR3CO2R4, NR3CONR4, can be optionally substituted with halo, amino, hydroxyl, C1-6 hydrocarbyl, C1-6 alkoxy, cyano, or phosphonic acid;
- and
- R2, R3 and R4 are independently selected from hydrogen, C1-6 hydrocarbyl, in which each of the C1-6 hydrocarbyl can be optionally substituted with halo, amino, hydroxyl, C1-6 alkoxy, cyano, or phosphonic acid;
- (b) Formula II is
- wherein,
- A is R, Y is O or S, X is NH2, OH, or OR, and G is R, where R is C1-16 hydrocarbyl;
- R1 is selected from halogen, cyano, OH, C1-6 hydrocarbyl, C1-6 alkoxy, SOR2, SO2R2, SO2NR3R4, CONR3R4, NR3R4, NR3COR4, NR3SO2R4, NR3CO2R4, NR3CONR4, and phosphonic acid, wherein each of C1-6 hydrocarbyl, C1-6 alkoxy, SOR2, SO2R2, SO2NR3R4, CONR3R4, NR3R4, NR3COR4, NR3SO2R4, NR3CO2R4, NR3CONR4, can be optionally substituted with halo, amino, hydroxyl, C1-6 hydrocarbyl, C1-6 alkoxy, cyano, or phosphonic acid;
- and
- R2, R3 and R4 are independently selected from hydrogen, C1-6 hydrocarbyl, in which each of the C1-6 hydrocarbyl can be optionally substituted with halo, amino, hydroxyl, C1-6 alkoxy, cyano, or phosphonic acid;
- or
- (c) Formula III:
- wherein,
- A is H, C1-20 hydrocarbyl, alkylaryl, or optionally R1 substituted C1-20 hydrocarbyl;
- Z is O or a bond;
- G is OH, H, C1-6—COO-alkyl, —O—C1-6 alkyl, R1 substituted C1-10 hydrocarbyl, CH2NHCH2COOH, or O-aryl;
- R1 is selected from halogen, cyano, OH, C1-6 hydrocarbyl, C1-6 alkoxy, SOR2, SO2R2, SONR3R4, CONR3R4, NR3R4, NR3COR4, NR3SOR4, NR3COR4, NR3CONR4, and phosphonic acid, wherein each of C1-6 hydrocarbyl, C1-6 alkoxy, SOR2, SO2R2, SO2NR3R4, CONR3R4, NR3R4, NR3COR4, NR3SO2R4, NR3CO2R4, NR3CONR4, can be optionally substituted with halo, amino, hydroxyl, C1-6 hydrocarbyl, C1-6 alkoxy, cyano, or phosphonic acid;
- and
- R2, R3 and R4 are independently selected from hydrogen, C1-6 hydrocarbyl, in which each of the C1-6 hydrocarbyl can be optionally substituted with halo, amino, hydroxyl, C1-6 alkoxy, cyano, or phosphonic acid.
A composition comprising one or more organophosphorous and/or organosulfurous compounds, salts thereof, solvates thereof, or derivatives thereof, in an effective amount to enhance the growth of yeast and algae, wherein the organophosphorous and/or organosulfurous compound has the structure of Formula I, Formula II, or Formula III, and wherein
- (a) Formula I is
- wherein,
- A is H, C1-16 hydrocarbyl or optionally R1 substituted C1-16 hydrocarbyl;
- Z is 0 or a bond;
- Y is O;
- G is OH, H, C1-6—COO-alkyl, —O—C1-16 alkyl, R1 substituted C1-10 hydrocarbyl, CH2NHCH2COOH, or O-aryl;
- X is H, CN, —NHR, —NHOR, —NHOCOR, R1 substituted C1-10 hydrocarbyl or —OR;
- and R is H, C1-10 hydrocarbyl, or optionally R1 substituted C1-10 hydrocarbyl;
- R1 is selected from halogen, cyano, OH, C1-6 hydrocarbyl, C1-6 alkoxy, SOR2, SO2R2, SO2NR3R4, CONR3R4, NR3R4, NR3COR4, NR3SO2R4, NR3CO2R4, NR3CONR4, and phosphonic acid, wherein each of C1-6 hydrocarbyl, C1-6 alkoxy, SOR2, SO2R2, SO2NR3R4, CONR3R4, NR3R4, NR3COR4, NR3SO2R4, NR3CO2R4, NR3CONR4, can be optionally substituted with halo, amino, hydroxyl, C1-6 hydrocarbyl, C1-6 alkoxy, cyano, or phosphonic acid;
- and
- R2, R3 and R4 are independently selected from hydrogen, C1-6 hydrocarbyl, in which each of the C1-6 hydrocarbyl can be optionally substituted with halo, amino, hydroxyl, C1-6 alkoxy, cyano, or phosphonic acid;
- (b) Formula II is
- wherein,
- A is R, Y is O or S, X is NH2, OH, or OR, and G is R, where R is C1-16 hydrocarbyl;
- R1 is selected from halogen, cyano, OH, C1-6 hydrocarbyl, C1-6 alkoxy, SOR2, SO2R2, SO2NR3R4, CONR3R4, NR3R4, NR3COR4, NR3SO2R4, NR3CO2R4, NR3CONR4, and phosphonic acid, wherein each of C1-6 hydrocarbyl, C1-6 alkoxy, SOR2, SO2R2, SO2NR3R4, CONR3R4, NR3R4, NR3COR4, NR3SO2R4, NR3CO2R4, NR3CONR4, can be optionally substituted with halo, amino, hydroxyl, C1-6 hydrocarbyl, C1-6 alkoxy, cyano, or phosphonic acid;
- and
- R2, R3 and R4 are independently selected from hydrogen, C1-6 hydrocarbyl, in which each of the C1-6 hydrocarbyl can be optionally substituted with halo, amino, hydroxyl, C1-6 alkoxy, cyano, or phosphonic acid;
- or
- (c) Formula III:
- wherein,
- A is H, C1-20 hydrocarbyl, alkylaryl, or optionally R1 substituted C1-20 hydrocarbyl;
- Z is O or a bond;
- G is OH, H, C1-6—COO-alkyl, —O—C1-6 alkyl, R1 substituted C1-10 hydrocarbyl, CH2NHCH2COOH, or O-aryl;
- R1 is selected from halogen, cyano, OH, C1-6 hydrocarbyl, C1-6 alkoxy, SOR2, SO2R2, SONR3R4, CONR3R4, NR3R4, NR3COR4, NR3SOR4, NR3COR4, NR3CONR4, and phosphonic acid, wherein each of C1-6 hydrocarbyl, C1-6 alkoxy, SOR2, SO2R2, SO2NR3R4, CONR3R4, NR3R4, NR3COR4, NR3SO2R4, NR3CO2R4, NR3CONR4, can be optionally substituted with halo, amino, hydroxyl, C1-6 hydrocarbyl, C1-6 alkoxy, cyano, or phosphonic acid;
- and
- R2, R3 and R4 are independently selected from hydrogen, C1-6 hydrocarbyl, in which each of the C1-6 hydrocarbyl can be optionally substituted with halo, amino, hydroxyl, C1-6 alkoxy, cyano, or phosphonic acid.
Dependencies are inferred from the claim text.