Tissue Imaging Replicas
AssigneeStandard BioTools Canada Inc.
InventorAlexander LOBODA
Life of this patent
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Abstract
A method of imaging a biological sample is disclosed, which comprises coupling at least one affinity probe to the biological sample, wherein the affinity probe includes a cleavable tag, bringing the probe-coupled biological sample into contact with a non-selective capture surface so as to couple said at least one cleavable tag to the capture surface, subsequently, cleaving the at least one tag from the affinity probe so as to transfer the at least one tag to the capture surface, thereby generating a replica of the biological sample.
Claims29
A method of imaging a biological sample, comprising:
- coupling at least one affinity probe to the biological sample, wherein the at least one affinity probe includes at least one cleavable tag, thereby creating a probe-coupled biological sample,
- bringing the probe-coupled biological sample into contact with, or in proximity of, a capture surface so as to couple said at least one cleavable tag to the capture surface, and
- cleaving the at least one cleavable tag from the affinity probe, thereby generating a replica of the biological sample.
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A method of imaging a biological sample, comprising:
- coupling at least one affinity probe to the biological sample, wherein the at least one affinity probe includes at least one cleavable tag,
- transferring the at least one cleavable tag from the biological sample to a non-selective capture surface such that a spatial distribution of the transferred at least one cleavable tag on the non-selective capture surface substantially retains relative spatial distribution of the at least one affinity probe coupled to the biological sample.
Dependencies are inferred from the claim text.