Dehydrogenase mutants and applications thereof in amino acid synthesis
AssigneeMetabolic Explorer
InventorsPerrine VASSEUR, Jean-Baptiste BOUDON, Laurence DUMON-SEIGNOVERT, Céline RAYNAUD, Thomas DESFOUGERES
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Abstract
The present invention relates to a modified dehydrogenase, wherein one or more amino acid residues of the dehydrogenase are modified as compared to an unmodified dehydrogenase, and wherein the modified dehydrogenase has an increased ratio of leucine dehydrogenase or isoleucine dehydrogenase activity to valine dehydrogenase activity as compared to the unmodified dehydrogenase, and applications thereof.
Claims15
A modified dehydrogenase, wherein one or more amino acid residues of the dehydrogenase are modified as compared to an unmodified dehydrogenase, and wherein the modified dehydrogenase has an increased ratio of leucine dehydrogenase or isoleucine dehydrogenase activity to valine dehydrogenase activity as compared to the unmodified dehydrogenase.
Dependencies are inferred from the claim text.