Multi-chain chimeric polypeptides and uses thereof
AssigneeHCW Biologics, Inc.
InventorHing C. Wong
Life of this patent
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Abstract
Provided herein are multi-chain chimeric polypeptides that include: (a) a first chimeric polypeptide including a first target-binding domain a soluble T cell receptor β-chain constant region (TRβC) domain, and a first domain of a pair of affinity domains; and (b) a second chimeric polypeptide including a second domain of a pair of affinity domains and a second target-binding domain, where the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains. Also provided here are methods of using these multi-chain chimeric polypeptides and nucleic acids encoding these multi-chain chimeric polypeptides.
Claims42
A multi-chain chimeric polypeptide comprising:
- (a) a first chimeric polypeptide comprising:
- (i) a first target-binding domain;
- (ii) a soluble T cell receptor β-chain constant region (TRβC) domain;
- and
- (iii) a first domain of a pair of affinity domains;
- and
- (b) a second chimeric polypeptide comprising:
- (i) a second domain of a pair of affinity domains;
- and
- (ii) a second target-binding domain,
- wherein the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains.
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Dependencies are inferred from the claim text.