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US 2026/0132159 A1Published application
Gold containing compounds and methods of use
OwnerSamuel G. Awuahinventor
Life of this patent
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Abstract
The presently-disclosed subject matter includes useful water-soluble gold containing compounds and compositions, and methods of making and methods of using such compounds and compositions.
Claims20
A compound of the formula:
- wherein R1 and R2, taken together with the gold (Au) to which they are bound, form a polycyclic moiety selected from the group consisting of:
- X is selected from the group consisting of CH2, O, NH, C═O, C═NO-alkynyl, S, or aryl;
- R3, R4, R5, R6 are each independently selected from the group consisting of H, alkyl, and aryl, or R3 and R4 and/or R5 and R6, taken together with the phosphorus (P) to which they are bound, form a cyclic moiety;
- R7 and R8, together with the phosphorus (P) to which they are bound, form a structure selected from the group consisting of:
- in which m is 1, 2, or 3;
- R9 is H, alkyl, or aryl;
- R10 is H, alkyl, aryl, or taken together with two of the atoms of the ring to which it is bound, forms a 6-membered ring;
- Y is C or N;
- L is a linker group;
- and
- W is a water soluble group;
- or a pharmaceutically acceptable salt thereof.
9 more elements
A compound of the formula:
- wherein
- X is selected from the group consisting of CH2, O, NH, C═O, C═NO-alkynyl, S, or aryl;
- R1 and R2 are independently selected the group consisting of alkyl and substituted alkyl, or, R1 and R2, taken together with the N to which they are bound, form a piperidine or piperazine that is optionally substituted with Z;
- Z is selected from the group consisting of haloaryl and alkoxyaryl;
- L is a linker group;
- and
- W is a water soluble group.
4 more elements
A method of making the compound
- comprising reacting
- with sorbitol and/or glucamine in the presence of 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC), 1-hydroxybenzotriazole (HOBt), and anhydrous dimethylformamide (anh.DMF).
Dependencies are inferred from the claim text.