Methods of preparing isomers, analogs, and synthetic derivatives from akuamma seeds

A method for producing a synthetic compound from alkaloids obtained from akuamma, comprising:

• drying akuamma seeds in an oven at a temperature from about 20° C. to about 60° C., for a period of time from about 12 hours to about 36 hours, and grinding the akuamma seeds to produce a powdered akuamma;
• dissolving a predetermined amount of the powdered akuamma in a solvent to form a first solution;
• subjecting the first solution to an extraction process to recover a first extract possessing the alkaloids from the akuamma;
• concentrating the first extract to obtain a second extract;
• purifying the second extract using liquid-liquid extraction to obtain a third extract;
• isolating the alkaloids from the third extract;
• collecting the alkaloids;
• and
• converting the alkaloids to the synthetic compound by a reaction selected from deprotonation, oxidation, alkylation, acylation, halogenation, or ring modification reactions.