Drug delivery devices and methods for administering substances to a body cavity by heterogenous aerosolization for treatment of binge-eating disorders and/or obesity

A device for delivering a volume Vsub [ml or mg] of at least one substance, within a body cavity of a subject for the treatment of a condition selected from (i) frequent and recurrent binge eating episodes, (ii) behavioral syndromes associated with physiological disturbances and physical factors (F50-F59 under fifth chapter of the ICD-10:

• Mental and behavioral disorders), (iii) obesity;
• (iv) OCD;
• (v) psychiatric conditions and mental disorders;
• (vi) migraines;
• (vii) pain;
• and, (viii) any combination thereof, comprising:
• a. at least one vial enclosing the volume Vsub [ml or mg] of said at least one substance;
• said at least one vial having at least one fluid discharging outlet port having an outlet diameter Dout[mm], configured for placement in proximity to said body cavity of the subject;
• and
• b. an activation mechanism comprising a base, the activation mechanism adapted to, upon actuation, to release said at least one substance within said body cavity in the form of an aerosol;
• wherein the fluid discharging outlet port is structured such that the aerosol forms a bi-modal spray pattern;
• wherein said body cavity is a nasal cavity.