Fibers electrospinning including microfluidics method
AssigneesUniversity of Tartu, Institute of Fundamental Technological Research
InventorsGeorg-Marten LANNO, Tomasz KOWALCZYK, Slawomir BLONSKI, Marta PUTRINŠ, Tanel TENSON, Piotr KORCZYK, Karin KOGERMANN
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Abstract
The present invention relates to methods for the encapsulation of bioactive entities, and formation into solid materials. The method comprises encapsulation of a bioactive entity via microfluidics and electrospinning into polymer fibres. The invention also relates to electrospun polymer fibres comprising bioactive entity-containing hydrophilic and/or gel-forming polymer microparticles embedded within fibres of at least one hydrophobic polymer. The invention also relates to a wound dressing comprising the electrospun fibres.
Claims26
A method for producing electrospun polymer fibres comprising bioactive entity-containing microparticles, the method comprising the steps:
- (a) encapsulation of a bioactive entity via microfluidics;
- and
- (b) electrospinning into polymer fibres,
- wherein encapsulation and electrospinning are performed using a single apparatus.
The method of any preceding claim, wherein the continuous phase is a hydrophobic polymer solution in organic solvent.
The method of any preceding claim, wherein the bioactive entity comprises bacteria, and wherein the bacteria produce a desired substance.
Electrospun polymer fibres comprising bioactive entity-containing hydrophilic and/or gel-forming polymer microparticles embedded within fibres of at least one hydrophobic polymer.
An apparatus comprising a microfluidic device and an electrospinning device comprising at least two devices inducing flow, a microfluidic device, a nozzle, a high-voltage power supply, a grounded collection plate and an electrospinning device, wherein the microfluidic device comprises at least two input channels and at least one output channel, wherein the first liquid is an aqueous solution containing bioactive entity, the second input liquid is a polymer solution in organic solvent, the microfluidic device is configured such that the two input liquids introduced to dedicated input channels meet and generate a polymer solution comprising entrained microcapsules of bioactive entity, which pass to the nozzle, and the nozzle is held at a potential of +3-60 kV or −3-60 kV relative to the grounded collection plate.
Dependencies are inferred from the claim text.