US 2026/0131027 A1 · Composition and Use Method Therefor

Abstract

An aging reprogramming composition, a use method therefor, a kit containing the composition, and the use of the composition in tissue repair, tissue regeneration, organ regeneration, aging reversion, or any combination thereof. The present invention relates to SOX1, SOX2, SOX3, RCOR2, GMNN, GATA1, GATA2, GATA3, GATA4, GATA6, FOXA2, SOX7, SOX17, NKX3.1, NR5A2, C/EBPα, OCT4, PAX1, Klf4, Klf2, GLIS1 and c-MYC, which are used as inducing factors to reprogram cells, tissues or organs to restore a youthful state. Provided is a composition of an activation inducing factor in the form of an engineered nucleic acid, an engineered cell, an engineered protein, a chemical agent, or any combination thereof, wherein the composition is used for treating diseases, preventing diseases, modulating tissue repair, modulating tissue regeneration, or any combination thereof.

Claims15

Dependent claims

A composition for rejuvenating a cell, tissue, or organ of a subject, wherein the composition comprises:

i) any one factor selected from the group consisting of SOX1, SOX2, SOX3, RCOR2, GMNN, and GLIS1,
ii) any one factor selected from the group consisting of GATA1, GATA2, GATA3, GATA4, GATA6, FOXA2, SOX7, SOX17, NKX3.1, NR5A2, C/EBPα, OCT4, and PAX1, and
iii) factor Klf4 or Klf2.

A kit comprising an inducing factor for rejuvenating somatic cells in a subject, characterized in that, the inducing factor comprises:

i) any one factor selected from the group consisting of SOX1, SOX2, SOX3, RCOR2, GMNN, and GLIS1,
ii) any one factor selected from the group consisting of GATA1, GATA2, GATA3, GATA4, GATA6, FOXA2, SOX7, SOX17, NKX3.1, NR5A2, C/EBPα, OCT4, and PAX1, and
iii) factor Klf4 or Klf2.

Dependencies are inferred from the claim text.

Facts

Application

19/445,313Filed 9 Jan 2026

Priority

CN 202310849960.411 Jul 2023

Published

14 May 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification27 codes

A61K 48/005
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy:…
C12N 5/0656
Cells of skeletal and connective tissues; Mesenchyme: adult fibroblasts
A61K 38/1709
From vertebrates: from mammals
A61K 38/179
Receptors; Cell surface antigens; Cell surface determinants: for growth factors; for growth regulators

Composition and Use Method Therefor

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Composition and Use Method Therefor

Life of this patent

Abstract

Claims15