Hyaluronic acid based drug delivery systems
AssigneeCella Therapeutics, LLC
InventorsRhett Schiffman, Patrick Hughes
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Abstract
The present disclosure provides a hyaluronic acid-based drug delivery system comprising a compound of Formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein X, R1, and R2 are as defined herein. The present disclosure also provides compositions comprising the hyaluronic acid-based drug delivery system described herein and one or more active pharmaceutical ingredient(s). The present disclosure also provides methods of delivering one or more active pharmaceutical ingredient(s) to the eye of a subject in need thereof and methods of treating ophthalmic diseases, disorders, or conditions in a subject in need thereof, comprising administering a composition disclosed herein to the subject.
Claims26
Hyaluronic acid comprising a compound of Formula (I):
- or a salt or solvate thereof, wherein:
- n is an integer from 500 to 25,000;
- X at each occurrence is selected from the group consisting of —NH— and —O—;
- R1 and R2 at each occurrence are independently selected from the group consisting of hydrogen, a hydrophobic group, -LJ-L2-A, and -A;
- each L1 is an amino acid or absent;
- each L2 is a linker;
- and
- each A is independently a covalently bonded active pharmaceutical ingredient, wherein each instance of -A can be the same or different.
Dependencies are inferred from the claim text.