Nanoparticles for delivery of immunoregulatory materials to t cells
AssigneeThe Johns Hopkins University
InventorsJonathan Schneck, Ariel Isser
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Abstract
Artificial antigen presenting cells (aAPC) including a major histocompatibility class II (MHC II) molecule and methods of their use for identifying, isolating, or detecting one or more antigen-specific T cells, and treating a disease, disorder, or condition, including cancer, are disclosed.
Claims74
An artificial antigen presenting cell (aAPC) comprising a particle having a major histocompatibility complex class II (MHC II) molecule conjugated to a surface thereof.
An artificial antigen presenting cell (aAPC) consisting essentially of a particle having a major histocompatibility complex class II (MHC II) molecule conjugated to a surface thereof.
An aAPC having an HLA class I molecule and an HLA class II molecule conjugated to a surface thereof.
Dependencies are inferred from the claim text.