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US 2026/0130951 A1Published application
Glycyrrhizin-glycol chitosan conjugate-coated iron oxide nanoparticles and use thereof
AssigneeIndustry-University Cooperation Foundation Hanyang University
InventorsDong Yun LEE, Su Bin JANG, Sangjoon LEE
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Abstract
The present invention relates to glycyrrhizin-glycol chitosan conjugate-coated nanoparticles, islet cells, prepared using same, for transplantation, and an MRI imaging composition comprising same. If transplanted, the islet cells comprising the nanoparticles can suppress a post-transplantation immune response. The present invention can provide islet cells for transplantation that can be transplanted to a certain region by magnetic force induction and can be tracked by MRI.
Claims9
A method for preparing islet cells for transplantation, the method comprising:
- (a) bringing a composition for transplanting islet cells into contact with islet cells isolated from a donor;
- (b) applying a magnetic force to the islet cells for 0.1 to 5 minutes;
- and
- (c) mixing the resulting product of (b) for 0.1 to 5 minutes,
- wherein the composition comprises nanoparticles coated with glycol chitosan-glycyrrhizin conjugate, and the glycol chitosan-glycyrrhizin conjugate is linked by a covalent bond.
2 more elements
Dependencies are inferred from the claim text.