Lubricating block copolymers and their use as biomimetic boundary lubricants
AssigneeCornell University
InventorsDavid PUTNAM, Lawrence BONASSAR, Zhexun SUN
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Abstract
The invention relates to methods of lubricating biological tissue, such as joints, bone, ocular tissue, nasal tissue, tendons, tendon capsule, and vaginal tissue, by contacting the biological tissue with an effective amount of a block copolymer lubricating composition which functions at least or better than lubricin. In particular embodiments, the method is used to treat osteoarthritis. In specific embodiments, the block copolymer has an ammonium-containing polymer block and a non-ionic hydrophilic polymer block, or the copolymer has a carboxylic acid-containing polymer block and a non-acid non-ionic hydrophilic polymer block.
Claims21
A block copolymer having the following structure:
- wherein:
- R1, R2, and R3 are independently selected from hydrocarbon groups having at least one and up to twelve carbon atoms;
- X and X′ are independently selected from —NR′—, —O—, and a bond, wherein R′ is selected from hydrogen atom and hydrocarbon groups having at least one and up to six carbon atoms;
- Y is selected from polyalkylene glycol, saccharide, and polyalcohol;
- subscripts a and b are independently integers of at least 3;
- subscripts a and b are independently integers of no more than 2000;
- and
- subscript c is an integer of at least 1;
- wherein, by the laws of chemistry, the block copolymer is terminated on each end by terminal groups, and the total positive charge of quaternary ammonium groups in the copolymer is counterbalanced by a total negative charge of equivalent magnitude provided by anions associated with said ammonium groups.
A block copolymer having the following structure:
- wherein:
- X is selected from —NR′—, —O—, and a bond, wherein R′ is selected from hydrogen atom and hydrocarbon groups having at least one and up to six carbon atoms;
- Y is selected from polyalkylene glycol, saccharide, and polyalcohol;
- R is a hydrogen atom, hydrocarbon group (R) having 1-12 carbon atoms, or a cartilage binding domain;
- subscripts d and e are independently integers of at least 3;
- and
- subscript f is 0 or an integer of at least 1;
- wherein the hydrogen atom on the shown carboxylic acid group is optionally replaced with a positively charged metal ion or positively charged organic group;
- and
- wherein, by the laws of chemistry, the block copolymer is terminated on the end opposite to the thiol group by a terminal group.
A method for imparting a suitable level of lubricity to a biological tissue, the method comprising contacting said biological tissue with a sufficient amount of a composition to impart suitable lubricity, said composition comprising a block copolymer having the following structure:
- wherein:
- R1, R2, and R3 are independently selected from hydrocarbon groups having at least one and up to twelve carbon atoms;
- X and X′ are independently selected from —NR′—, —O—, and a bond, wherein R′ is selected from hydrogen atom and hydrocarbon groups having at least one and up to six carbon atoms;
- Y is selected from polyalkylene glycol, saccharide, and polyalcohol;
- subscripts a and b are independently integers of at least 3;
- and
- subscript c is an integer of at least 1;
- wherein, by the laws of chemistry, the block copolymer is terminated on each end by terminal groups, and the total positive charge of quaternary ammonium groups in the copolymer is counterbalanced by a total negative charge of equivalent magnitude provided by anions associated with said ammonium groups.
A method for imparting a suitable level of lubricity to a biological tissue, the method comprising contacting said biological tissue with a sufficient amount of a composition to impart suitable lubricity, said composition comprising a block copolymer having the following structure:
- X is selected from —NR′—and —O—, wherein R′ is selected from hydrogen atom and hydrocarbon groups having at least one and up to six carbon atoms;
- Y is selected from polyalkylene glycol, saccharide, and polyalcohol;
- R is a hydrogen atom, hydrocarbon group (R) having 1-12 carbon atoms, or a cartilage binding domain;
- subscripts d and e are independently integers of at least 3;
- and
- subscript f is 0 or an integer of at least 1;
- wherein the hydrogen atom on the shown carboxylic acid group is optionally replaced with a positively charged metal ion or positively charged organic group;
- and
- wherein, by the laws of chemistry, the block copolymer is terminated on the end opposite to the thiol group by a terminal group.
(canceled)
Dependencies are inferred from the claim text.