Methods and compounds modifying mitochondrial function
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsXinnan Wang, Chung-Han Hsieh, Roeland Vanhauwaert
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Abstract
The invention provides methods for identifying modulators of mitochondrial function for therapeutic use in neurodegenerative disorder. The invention provides method for identifying subjects who may benefit from the therapeutic agents.
Claims24
1-7. (canceled)
A method to determine the MIRO1 status of a subject comprising measuring the Miro1 response to mitochondrial depolarization using biochemical assays, western blotting or ELISA, to determine if a subject is deficient in the removal of MIRO1 following depolarization, wherein a subject deficient in the removal of MIRO1 following depolarization is selected for treatment by administration of a MIRO1 reducer.
20-38. (canceled)
A method for selecting a subject for treatment with a therapeutic agent for a neurodegenerative disorder, comprising:
- (a) collecting cells from the subject and evaluating a first control portion of the cells for the pre-depolarization Miro level in the cells;
- (b) contacting a second test portion of the cells with a depolarizing agent;
- and
- (c) evaluating the post-depolarization Miro level in the second test portion of cells contacted with the depolarizing agent and comparing the Miro level to the pre-depolarization Miro level in the first control portion of cells;
- wherein when the post-depolarization Miro level in the second test portion of cells is reduced by 40% or less relative to the pre-depolarization Miro level in the first control portion of cells, the subject is treated with a therapeutic agent for neurodegenerative disorder.
46-49. (canceled)
A method of improving a condition of aging, comprising administering to a subject in need thereof a Miro-reducing agent.
51-52. (canceled)
Dependencies are inferred from the claim text.