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US 2026/0125751 A1Published application
Cyanine derivatives and related uses
AssigneeElement Biosciences, Inc.
InventorsGenhua ZHENG, Njoo Audrey WIBAWA, Xi ZHANG, Zhimin YANG, Marcus James JELLEN, Gene SHEN
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Abstract
The present disclosure provides a compound of Formula (I), (II), or (III): an ionic derivative thereof, an isomer thereof, or a salt thereof. The present disclosure also provides conjugates of the compounds, and methods of using the compounds and the conjugates. The disclosure also provides the use of the compounds and conjugates in methods of sequencing nucleic acids.
Claims31
-30. (canceled)
A compound of Formula (I-B):
- or a salt, ionic derivative thereof, or conjugate thereof, wherein:
- n is 1;
- m is 0 or 1;
- R1A is H;
- R2A is H, —S(═O)2OH, —C(═O)NH—C1-12 alkyl optionally substituted with one or more RAR, wherein each RAR is —S(═O)2OH;
- R3A is H or —C(═O)OH;
- R4A is H, —C(═O)OH, or —C(═O)NH—C1-12 alkyl optionally substituted with one or more
- RAR, wherein each RAR is —S(═O)2OH;
- R1B is H;
- R2B is H, —S(═O)2OH, —C(═O)NH—C1-12 alkyl optionally substituted with one or more RBR, wherein each RBR is —S(═O)2OH;
- R3B is H or —C(═O)NH—C1-12 alkyl optionally substituted with one or more RBR, wherein each RBR is —S(═O)2OH;
- R4B is H, —S(═O)2OH, or —C(═O)NH—C1-12 alkyl optionally substituted with one or more
- RBR, wherein each RBR is —S(═O)2OH;
- each RTA independently is C1-6 alkyl optionally substituted with one or more —S(═O)2OH;
- or —C(═O)OH;
- each RTB independently is C1-6 alkyl optionally substituted with one or more —S(═O)2OH or —C(═O)OH;
- RNA is C1-6 alkyl optionally substituted with one or more —S(═O)2OH;
- and
- RNB is C1-6 alkyl optionally substituted with one or more —S(═O)2OH;
- wherein (i) at least one of RTA and RTB comprises —SO3H, (ii) three of R2A, R2B, R4A, and R4B are —SO3H, or (iii) at least one of R2A, R4A, R4B, and R2B is C(═O)NHCH2CH2SO3H.
17 more elements
A compound of Formula (II-B):
- or a salt or ionic derivative thereof, wherein:
- n is 1;
- m is 0 or 1;
- R1A is H;
- R2A is H;
- R5A is H or —S(═O)2OH;
- R6A is H;
- R7A is H or —S(═O)2OH;
- R1A is H;
- R1B is H;
- R2B is H, —S(═O)2OH, or —C(═O)NH—C1-12 alkyl optionally substituted with one or more RBR, wherein each RBR is —S(═O)2OH;
- R3B is H;
- R4B is H, —S(═O)2OH, or —C(═O)NH—C1-12 alkyl optionally substituted with one or more RBR, wherein each RBR is —S(═O)2OH;
- each RTA independently is C1-6 alkyl optionally substituted with one or more —C(═O)OH;
- each RTB independently is C1-6 alkyl optionally substituted with one or more —C(═O)OH;
- RNA is C1-6 alkyl optionally substituted with one or more —S(═O)2OH;
- and
- RNB is C1-6 alkyl optionally substituted with one or more —S(═O)2OH.
15 more elements
A compound of Formula (III-b)
- n is 1;
- m is 1;
- R1A is H;
- R2A is H;
- R5A is H or —S(═O)2OH;
- R6A is H;
- R7A is H or —S(═O)2OH;
- R1A is H;
- R1B is H;
- R2B is H;
- R5B is H or —S(═O)2OH;
- R6B is H;
- R7B is H or —S(═O)2OH;
- R8B is H;
- each RTA independently is C1-6 alkyl optionally substituted with one or more —C(═O)OH;
- each RTB independently is C1-6 alkyl optionally substituted with one or more —C(═O)OH;
- RNA is C1-6 alkyl optionally substituted with one or more —S(═O)2OH;
- and
- RNB is C1-6 alkyl optionally substituted with one or more —S(═O)2OH.
16 more elements
Dependencies are inferred from the claim text.