Simulation apparatus, simulation system, and simulation method for simulating cell proliferation by a cell culture apparatus

A simulation system for simulating cell proliferation in a cell culture apparatus, the simulation system comprising:

• a simulation execution unit configured to simulate a change in concentration of a protein in an inner circulation path of the cell culture apparatus using a supply speed, an exchange speed, and a deterioration speed,
• a predetermined or selected culture condition being applied in the inner circulation path,
• the cell culture apparatus including a hollow fiber membrane and the inner circulation path defined by an inner channel of the hollow fiber membrane,
• the supply speed being a first speed at which a first concentration of the protein in the inner circulation path changes as a result of the supply of a culture medium to the inner circulation path,
• the exchange speed being a second speed at which a second concentration of the protein in the inner circulation path changes as a result of inflow and outflow of the culture medium between the inner circulation path and an outer region of the inner circulation path, and
• the deterioration speed being a third speed at which a third concentration of the protein in the inner circulation path changes as a result of deterioration of the protein;
• and
• a display control unit configured to control a display unit of the cell culture apparatus including to display information according to the change in concentration obtained by the simulation.

A simulation method for simulating cell proliferation in a cell culture apparatus, the simulation method comprising:

• simulating a change in concentration of a protein in a circulation path of the cell culture apparatus using a supply speed, an exchange speed, and a deterioration speed,
• a predetermined or selected culture condition being applied in the circulation path,
• the supply speed being a first speed at which a first concentration of the protein in the circulation path changes as a result of the supply of a culture medium to the circulation path,
• the exchange speed being a second speed at which a second concentration of the protein in the circulation path changes as a result of inflow and outflow of the culture medium between the circulation path and an outer region of the circulation path, and
• the deterioration speed being a third speed at which a third concentration of the protein in the circulation path changes as a result of deterioration of the protein.