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US 2026/0125614 A1Published application
Ionizable cationic lipids
AssigneeAkagera Medicines, Inc.
InventorsDaryl C. Drummond, Dmitri B. Kirpotin, Mark E. Hayes
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Abstract
The present disclosure provides compounds useful as ionizable cationic lipids. The ionizable cationic lipids are useful for preparing lipid nanoparticles for the delivery of therapeutic nucleic acids to cells. Cationic ionizable lipids were engineered with improved stability to oxidative degradation while in storage.
Claims20
A compound having a structure of Formula (IV-B)
- or pharmaceutically acceptable salt thereof, wherein:
- Y is
- each R22 is independently a linear polyunsaturated hydrocarbon lipid tail consisting of saturated alkyl groups on both ends of a pair of cis-oriented olefin double bonds separated by at least two methylene groups between the olefins within each R22 hydrocarbon chain;
- L is
- v is 0 or 1;
- q2 is 1 or 2;
- n is 1, 2, 3 or 4;
- and
- R10 and R12 are each independently selected from an alkyl group selected from the group consisting of:
- methyl, ethyl, and n-propyl, wherein the alkyl in R10 and R12 is optionally substituted with one or more hydroxyl.
7 more elements
Dependencies are inferred from the claim text.