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OwnerBryan WITTMANN, Matthew HART +3inventors
InventorsBryan WITTMANN, Matthew HART, Max ALLSWORTH, Marc VAN DER SCHEE, Christiaan LABUSCHAGNE
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The invention relates to a compound of the formula Xm—(Y-L-T)n and a method for the detection or prognosis of a disease in the exhaled breath of a subject. X, when present is a moiety operable to target the compound to a site of interest in vivo; m is (or at least 1, Y is a cleavable group; L is a self-immolative linker, T is a terminating moiety, and n is 1 when m is 0 or n is at least 1 when m is at least 1, L is a self-immolative linker. The terminating moiety, T, may comprise an isotopically labelled reporter molecule or a precursor thereof. The reporter molecule is operable to be released upon cleavage of the cleavable group, Y; and the reporter molecule, upon release, is a volatile compound.
A compound of the formula Xm—(Y-L-T)n, wherein X, when present is a moiety operable to target the compound to a site of interest in vivo;
The compound according to any preceding claim, wherein m is 1 and n is 1.
The compound according to any preceding claim, wherein X comprises an antigen-binding moiety, a ligand for a cell surface receptor, a pHLIP, and/or a nanoparticle.
The compound according to any preceding claim, wherein the self-immolative linker, L, comprises a methylene carbamate group, an aminobenzyl carbamate group, an aminobenzyl carbonate group, an aminobenzyl ether group, a dithiobenzyl carbamate group, a dithiobenzyl carbonate group and/or a dithiobenzyl ether group.
The compound according to any preceding claim, wherein the self-immolative linker is of the formula:
The compound according to any preceding claim, wherein the terminating moiety, T, comprises hydrogen, a C1-C10 alkyl group, a C2-C10 alkenyl group, a C2-C10 alkynyl group, an aryl group, a therapeutically active agent and/or a molecular label.
The compound according to any preceding claim, wherein the self-immolative linker, L, comprises a reporter molecule.
The compound according to any preceding claim, wherein the terminating moiety, T, comprises a reporter molecule, for example a C1-C10 alkanol and/or a C2-C10 alkenol, or for example ethanol and/or trans-2-hexenol.
The compound according to any preceding claim, wherein the reporter molecule comprises carbon dioxide, a C1-C10 alkanol, a C2-C10 alkenol, a C1-C10 alkylamine, 2-imidazolidinone, a 1,3-di(C1-C6 alkyl)-2-imidazolidonone, iminoquinone methide and/or aminobenzyl alcohol.
The compound according to any preceding claim, wherein the isotopic label is 12C, 13C, 14C, 2H, 17O and/or 18O.
The compound according to any preceding claim, wherein the reporter molecule comprises at least two different isotopic labels.
The compound according to any preceding claim, wherein the cleavable group, Y, comprises a peptide and/or a glucuronide group.
The compound according to any preceding claim, comprising a further cleavable group, Y′, for example a further cleavable group covalently attached to the self-immolative group, L, such that the compound is of the formula Xm—(Y-L(Y′)-T)n.
The compound according to any preceding claim, wherein the cleavable group, Y, comprises a peptide and/or a glucuronide group;
Dependencies are inferred from the claim text.