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US 2026/0125367 A1Published application
Cancer treatments targeting cancer stem cells
AssigneeRemedy Plan, Inc.
InventorsGregory Thomas Crimmins, Dennise Alexandra De Jesús Diaz, Yushma Bhurruth-Alcor
Life of this patent
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Abstract
Disclosed are compounds, methods, compositions, and kits that allow for treating cancer by, e.g., targeting cancer stem cells. In some embodiments, the cancer is colorectal cancer, gastric cancer, gastrointestinal stromal tumor, ovarian cancer, lung cancer, breast cancer, pancreatic cancer, prostate cancer, testicular cancer, or lymphoma. In some embodiments, the cancer is liver cancer, endometrial cancer, leukemia, or multiple myeloma. The compounds utilized in the disclosure are of Formula (0), (O′), and (I):
Claims21
1-112. (canceled)
A compound of the formula:
- or a pharmaceutically acceptable salt, solvate, hydrate, polymorph, co-crystal, tautomer, stereoisomer, or isotopically labeled derivative thereof, wherein:
- R1 is substituted or unsubstituted, C1-6 alkyl;
- R2 is substituted or unsubstituted, C1-6 alkyl;
- R3 is hydrogen, halogen, substituted or unsubstituted, C1-6 alkyl, —ORa, —N(Ra)2, or —CN;
- each instance of R4 is independently hydrogen, halogen, substituted or unsubstituted, C1-6 alkyl, —ORa, —N(Ra)2, or —CN;
- each instance of R5 is independently hydrogen, halogen, substituted or unsubstituted, C1-6 alkyl, —ORa, —N(Ra)2, or —CN;
- each instance of Ra is independently hydrogen, substituted or unsubstituted, C1-6 alkyl, an oxygen protecting group when attached to an oxygen atom, or a nitrogen protecting group when attached to a nitrogen atom;
- each R6 is independently hydrogen, substituted or unsubstituted, C1-6 alkyl, substituted or unsubstituted, C2-6 alkenyl, substituted or unsubstituted, C2-6 alkynyl, substituted or unsubstituted, 3- to 13-membered, monocyclic or bicyclic carbocyclyl, substituted or unsubstituted, 3- to 13-membered, monocyclic or bicyclic heterocyclyl, substituted or unsubstituted, 6- to 11-membered, monocyclic or bicyclic aryl, substituted or unsubstituted, 5- to 11-membered, monocyclic or bicyclic heteroaryl, or a nitrogen protecting group;
- R7 is substituted or unsubstituted pyridinyl;
- and
- each instance of R8 is independently hydrogen, halogen, substituted or unsubstituted, C1-6 alkyl, —ORa, —N(Ra)2, or —CN.
8 more elements
Dependencies are inferred from the claim text.