Aryl hydrocarbon receptor activators

A compound of the formula:

• or a tautomer thereof, a stereoisomer thereof, a hydrate thereof, or a pharmaceutically acceptable salt thereof, wherein:
• Q1 is an optionally substituted C6-C10 aryl;
• optionally substituted C5-C10 heteroaryl;
• optionally substituted C5-C10 heterocyclyl;
• optionally substituted C1-C10 alkyl, or optionally substituted C3-C10 cycloalkyl;
• Z is C, S(O),
• or Z is CH when X1 is absent, or Z(X1)Q1 is H;
• X1 is absent, O, NH, S, or X1 is
• wherein the wavy lines denote points of attachment to Z;
• X2 is CQ2;
• Q2 is H, CN, CONH2, COOH, CF3, halogen, optionally substituted C1-C10 alkyl, optionally substituted C3-C10 cycloalkyl, optionally substituted C3-C10 heteroalkyl, optionally substituted C3-C10 heterocyclyl, optionally substituted C6-C14 aryl, or optionally substituted C5-C14 heteroaryl;
• R1 is H, optionally substituted C1-C10 alkyl, optionally substituted C3-C10 cycloalkyl, optionally substituted C3-C10 heteroalkyl, optionally substituted C3-C10 heterocyclyl, optionally substituted C6-C10 aryl, optionally substituted C5-C10 heteroaryl, or C1-C12 acyl;
• R2, R3, R4, and R5 are independently H, halogen, CN, optionally substituted C1-C10 alkyl, optionally substituted C3-C10 cycloalkyl, optionally substituted C1-C6 alkoxy, SO2R7, CO2R7, or CONR7R6, or any one of R2 and R3, R3 and R4, and R4 and R5 pairs, together with the carbon atoms to which they are attached, forms an optionally substituted a five- or six-membered cycloalkenyl, heterocyclenyl, aryl or heteroaryl;
• and
• R6 and R7 are independently H, optionally substituted C1-C10 alkyl, or optionally substituted C3-C10 cycloalkyl, or R6 and R7, together with the nitrogen atom to which they are attached, form an optionally substituted 5-membered ring or an optionally substituted 6-membered ring.