Ionizable cationic lipids
AssigneeTranslate Bio, Inc.
InventorsFrank DeRosa, Braydon Charles Guild, Michael Heartlein
Life of this patent
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Abstract
Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.
Claims29
1-34. (canceled)
A compound having the structure:
- wherein R1 and R2 are each independently selected from the group consisting of an optionally substituted, variably saturated or unsaturated C1-C20 alkyl and an optionally substituted, variably saturated or unsaturated C6-C20 acyl;
- wherein L1 and L2 are each independently selected from the group consisting of an optionally substituted C1-C30 alkyl, an optionally substituted variably unsaturated C1-C30 alkenyl, and an optionally substituted C1-C30 alkynyl;
- wherein m, n and o are each independently selected from the group consisting of zero and any positive integer.
36-45. (canceled)
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55-62. (canceled)
A compound having the structure:
- wherein R1 and R2 are each independently selected from the group consisting of an optionally substituted, variably saturated or unsaturated C1-C20 alkyl and an optionally substituted, variably saturated or unsaturated C6-C20 acyl;
- wherein L1 and L2 are each independently selected from the group consisting of an optionally substituted C1-C30 alkyl, an optionally substituted variably unsaturated C1-C30 alkenyl, and an optionally substituted C1-C30 alkynyl;
- and
- wherein x is selected from the group consisting of a C5-C20 alkyl and a variably unsaturated C1-C20 alkenyl.
64-75. (canceled)
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Dependencies are inferred from the claim text.