System and method for longitudinal anaysis of an organoid

Abstract

A system for longitudinal analysis of an organoid includes a region configured to support a Microelectrode Array (MEA) device carrying an organoid for longitudinal analysis. The MEA device includes a MEA supporting the organoid, a well configured to hold perfusion media for the organoid, a port for supplying the perfusion media to the well, and nodes in the MEA for sensing electrophysiological (EP) signals produced by the organoid from an interior of the organoid. The system further includes a perfusion media interface to a perfusion system. The system further includes a computing system configured to identify events in the EP signals for analysis based on predetermined criteria. The identified events include less than an entirety of each of the EP signals, provide a summary of the identified events, and analyze a user selected set of the identified events in the summary.

Dependencies are inferred from the claim text.