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AssigneesUniversitäT Bern, Institut FüR Virologie Und Immunologie (Ivi), Rocketvax AG
InventorsVolker THIEL, Nadine EBERT, Bettina Salome TRUEB, Güliz Tuba BARUT, Annika KRATZEL, Jörg JORES, Fabien LABROUSSAA, Martin BEER, Donata HOFFMANN, Jacob SCHÖN, Nico Joel HALWE, Lorenz ULRICH
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The invention relates to pharmaceutical product comprising a polynucleotide for use in the prevention or treatment of a SARS-CoV-2 virus infection wherein said SARS-CoV-2 virus is not a Wuhan wild-type SARS-CoV-2 virus. The polynucleotide encodes an attenuated human coronavirus or a fragment thereof, wherein the polynucleotide comprises at least 20 one-to-stop codons, wherein a one-to-stop codon is i) a different but synonymous codon compared to the corresponding codon in a natural human coronavirus genome and ii) differs by one nucleotide from a STOP codon.
A pharmaceutical product comprising a polynucleotide for use in the prevention or treatment of a SARS-CoV-2 virus infection,
The pharmaceutical product for use according to any one of the preceding claims, wherein the pharmaceutical product is administered intranasally or intramuscularly.
The pharmaceutical product for use according to any one of the preceding claims, wherein the natural human coronavirus genome is a natural SARS-CoV-2 genome, preferably
The pharmaceutical product for use according to any one of the preceding claims, wherein at least one of the one-to-stop codons is in a sequence encoding non-structural proteins;
The pharmaceutical product for use according to any one of the preceding claims, wherein the natural human coronavirus genome is a natural SARS-CoV-2 genome, and wherein at least one of the one-to-stop codons has a CDS codon number corresponding to a CDS codon number as indicated in Table 1 or supplementary Table 3 for SEQ ID NO:
The pharmaceutical product for use according to any one of the preceding claims, wherein the polynucleotide consists of or comprises a sequence as defined in SEQ ID NO:
Dependencies are inferred from the claim text.