Bioengineering teritiary lymphoid structures using chitosan-based hydrogels

Abstract

As disclosed herein, stromal cells are important for the recruitment and organization of lymphocytes in TLSs. Therefore, disclosed herein are composition and methods for bioengineering TLSs in animals, such as mice. These compositions involve chemokine-releasing microparticles or cells that can be implanted into the animals. Therefore, disclosed herein are chitosan hydrogels with chemokine-releasing microparticles or cells.

Dependencies are inferred from the claim text.